Picture this: a split-second fall, accident, or surgery complication robs someone you love of walking, feeling, independence – striking 27 million people worldwide with the cruel grip of chronic spinal cord injury (SCI). But what if paralysis wasn’t permanent? endParalysis Foundation is igniting that future, fueling bold research to restore sensation, movement, and full lives for those long past their injury.​

The Devastating Reach of SCI

SCI shatters more than mobility, it steals sensation, bladder/bowel control, sexual function, and for many, demands round-the-clock care or ventilators for breathing. Chronic cases, where scars block nerve regrowth years later, affect millions waiting for real cures. endParalysis targets this head-on, rejecting half-measures for therapies that biologically repair nerves, reduce scars, regrow axons, and replace tissue aimed squarely at people living with paralysis today.​

A Game-Changing Approach to a Cure

Unlike others, endParalysis accelerates cures through co-funding high-impact, goal-driven projects like gene therapies (e.g., EPFL’s nerve-regrowth tech restoring walking in chronic models) and “stress priming” axon repair from Blackmore/Perlmutter labs.

They bridge lab-to-clinic gaps with rigorous selection: pre-select projects based on chronic SCI applicability, biological plausibility (not electrical stimulation alone), and human translation potential, plus full transparency via multilingual annual reports.​​

100% of donations fuel research, board members cover operations.

Every gift targets functional biological repair for chronic SCI: scar clearance for plasticity, axon regrowth for brain-body links, tissue replacement for full reversal.

Real Momentum, Real Hope

Achievements stack up: Funded pilots led to larger grants; chronic gene therapy advanced to safety/replication phases; 2025 updates show nerve regrowth guiding to natural targets.

At events like Neuromove 2025, they rally scientists for focused chronic SCI investment – the largest patient pool needing solutions now.​

Join the charge to end paralysis: Donate directly (100% to research), leave a legacy gift, shop-to-donate, or tackle Unfreeze challenges (Body for physical feats, Mind for awareness). Track every step at endparalysis.org – your support powers the science turning “impossible” into independence.​

End paralysis stands apart because 100% of donations go directly to neuro-regenerative research. Operating costs are fully covered by board members, ensuring every dollar you give is invested in advancing treatments aimed at restoring function and improving quality of life for people living with chronic SCI.

With over 27 million people worldwide affected, SCI can happen suddenly from falls, accidents, or surgical complications, changing lives in an instant. Their mission is to fund research that is not only scientifically rigorous but also focused on therapies that can eventually be translated into real human treatments.

Their approach includes:

• Rigorous scientific project selection and validation
• Transparent reporting on how funds are spent and research progress
• Sharing accessible summaries of international pre-clinical and clinical research relevant to chronic SCI
• Supporting innovative therapies like gene therapy, scar reduction, nerve regrowth, and tissue repair

Support their work – moving closer to a future where paralysis from spinal cord injury is a thing of the past.

See more at https://endparalysis.org/

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